Sentence examples for gdp substrate from inspiring English sources

Thus, perhaps the h-site is created by the presence of bound GDP substrate, or bound dTTP, or both, but yes, different inferences are drawn from your figure 1 and 5 datasets when they are analyzed individually.

DOI: http://dx.doi.org/10.7554/eLife.07141.011 In contrast to the compact α2 barrel observed in our substrate/effector-bound α4β4 structures, no clamping motion of the barrel is observed between substrate-free α2 and a previously reported structure of α2 with GDP substrate and TTP effector bound (Eriksson et al., 1997).

The GDP-Man substrate of PimA is represented as red sticks sticks.

This decrease in signal could be due to depletion or degradation of the GDP-FucAz substrate, or it could reflect decreasing levels of endogenous fucosylation.

We have also shown for the first time that the presence of EF-Ts shifts the K M for the interaction of EF-Tu with its substrate GDP allowing EF-Tu to function at significantly lower concentrations of GDP.

We use the analogy that GDP is a substrate, and health determinants and widespread applications of public health research, treatments and interventions are catalysts that increase health and survival (Ad Hoc Committee on Health Research Relating to Future Intervention Options, 1996).

In addition, a decreased matrix ATP/ADP ratio due to increased energy consumption in activated neurons would also increase the availability of GDP for the substrate level phosphorylation and thus the overall activity of α-KGDHC [ 94].

TTP, which preferentially increases RNR activity for substrate GDP, binds to the specificity site such that only the carbonyl of Cys292 from loop 2 is positioned to form a hydrogen-bonding interaction with the thymine base.

The refined protein models show that besides the active-site residues Ser107, Tyr136 and Lys140, whose mutations impair the overall enzymatic activity and may affect the coenzyme binding mode, side-chains capable of proton exchange, located around the expected substrate (GDP-4-keto-6-deoxy-d-mannose) binding pocket, are selectively required during the epimerization and reduction steps.

(D) Structural comparison of WbnH and PimA in complex with the donor substrate GDP-Man (PDB code 2GEJ).

To further confirm this hypothesis, we performed a structural superposition of PimA alone (PDB code 4N9 W) and in complex with the donor substrate GDP-Man (PDB code 2GEJ) onto WbnH.