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This instability, leading to sustained oscillations, is a result of Ras varying between its active (GTP) and inactive (GDP) states.
Most small GTP-binding proteins change their binding affinity for protein partners between GTP and GDP states, and one could envision a similar role for a nucleotide switch in cargo selection and binding by metazoan LICs.
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The manufacturer's balance sheet and the country's GDP state that it is profitable.
As a percentage of state GDP, state and local spending went from 20.22% of GDP in 2004 to 19.76% in 2008 and 21.47% in 2009.
Phosphorylated TSC shifts Rheb to the inactive GDP state [ 2].
74 ARHGAP26 is a GTPase-activating protein that facilitates conversion of RHO GTPases to the GDP state and has been implicated in enhancing cellular motility.
The residues at these two homologous positions are crucial for hydrolysis of GTP in GTPases and their switch from the GTP state to the GDP state (Coleman et al, 1994).
In the GDP state Glu106 is exposed and points away from the bound nucleotide, a spatial arrangement that is incompatible with the formation of the dimer as suggested by the model.
In its GDP-state, however, in absence of Gic1 Cdc42 interacts directly with Cdc10 and thereby mechanically disassembles septin filaments.
Exchanges in the GTP- and GDP-state cycle are regulated by guanine nucleotide dissociation inhibitors (GDIs), GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs).
Conversely, in the GDP-state the G-domain contacts the membrane via helix α4 and α5 thus exposing the effector interaction site.
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