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Because GCs arise primarily from antigen stimulated follicular B cells, this may simply reflect the reduced number of follicular cells in aged animals.
While GCs arise from GCPs in the EGL and migrate across ML to IGL between P4 P21, Tbr2+ UBCs exit the RL during late embryonic stages, and then migrate through the PWM into the IGL until P10 (Englund et al., 2006; Sillitoe and Joyner, 2007; Mugnaini et al., 2011).
Approximately 1 3% of GCs arise as a result of inherited GC predisposition syndromes, such as hereditary diffuse GC (HDGC), caused by a germline mutation in the CDH1 gene, encoding E-cadherin, a molecule central in the processes of development, cell differentiation, and maintenance of epithelial architecture (Grunwald 1993).
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Resistance or insensitivity to Gcs occurs within inflamed tissues and insensitivity to the therapeutic properties of exogenous Gcs arises (4).
The purpose of this study was to determine whether the proinflammatory effect of GC arise from epigenetic pattern modifications in the regulatory regions of proinflammatory genes.
A typical assignment for a startup GC arises when a business idea confronts the question: how can we do this legally?
GCs may arise from the joint capsule, the ligaments, the tendon sheaths, the bursae, or the subchondral bone [1], being generally classified as juxta-articular, intra-articular or periosteal [2].
The coexistence of SCLC and GC in the presented case might indicate several possibilities: (1) GC may arise from SCLC via epithelial-to-mesenchymal transition, (2) SCLC may arise from GC through phenotypic conversion, and (3) SCLC and GC may have derived from a common neuroendocrine origin.
GC may arise from SCLC via EMT as SCLC progresses.
The gBGC hypothesis suggests that variation in GC content arises through variation in recombination rate across the genome.
In general, these histologic features are similar to the germinal center (GC) reactions that arise in peripheral lymphoid tissues during antigen-specific responses after immunization [ 42].
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