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Normal sulci have GCA grade 0, slight widening of sulci classifies as GCA 1, gyral volume loss is categorized as GCA 2 and pronounced widening of sulci with severe volume loss, so called "knife blade atrophy" is labelled GCA 3 (Fig. 3).
Φ : Histopathologically, the gross pathologic types were different for ESCC and GCA, in ESCC, 1: medullary; 2: fungating; 3: ulcerating; 4: constriction & intraluminal; in GCA, 1: protruding; 2: ulcerating; 3: infiltrating.
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p/19) GCA0 except for anterior gyri in both temporal lobes, GCA 2 3 left temporal and GCA1-2 rightemporalal.
Widening of sulci and gyral volume loss can be assessed using a 4-point scale, GCA 0 3 [32].
We have successfully utilized a family-based study design to localize several positional candidate preeclampsia susceptibility genes to chromosomes 2q22 ACVR2A, LCT, LRP1B, RND3, GCA), 5q (ERand) and 13q TNFSF13B).
Of the 100 referred, 98 had a biopsy, and of them, 15 were diagnosed with GCA (2 results were not included).
Geographical cellular-like architecture (GCA) [11], which is a backbone-based approach, defines a hierarchical hexagonal cluster architecture that basically adopts the concept of home-agent used in cellular networks.
Whilst our prior linkage- and association-based positional cloning studies in family- and population-based Australian cohorts, respectively, have discovered novel preeclampsia candidate genes (INHBB, ACVR2A, LCT, LRP1B, RND3, GCA, ERAP2, TNFSF13B), the full complement of causal genetic variation remains largely unknown.
GCA (NM_012198) protein expression was determined by immunofluorescence.
Additionally, we found that GCA 3'UTR reporter activity is regulated by miR-489 and -27a (Fig. S7).
These and other siRNA pools (GCA (NM_012198) and SLC22A2 (NM_003058)) were used at the concentration of 50 nM.
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