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To determine whether this is a general feature of leaky-late promoters, we have carried out a detailed analysis of the VP16 promoter in the context of the viral genome at the gC locus.
In this study, an association between a polymorphism of rs2282679 in the GC locus and serum 25(OH D concentration was validated in Japanese patients with RA.
This is the first report that a SNP P7 in the GC locus was associated with the risk for hip fracture.
Mauve alignments of the GC locus in A. fischerianus and A. fumigatus (supplementary fig. S5, Supplementary Material online) reveal alternative sets of genes totaling a similar length of ∼12 kb.
Similar analysis of a large Han Chinese cohort (n = 3210) found four SNPs at the GC locus (D432E, T436K, rs2282679 and rs1155563) significantly associated with lower plasma 25(OH D 42.
A multivariate Cox proportional hazards regression model adjusted for the independent non-genetic risk factors indicated that homozygous for the risk allele of rs2282679 in the GC locus regarding low serum 25(OH D concentration was significantly associated with the occurrence of hip fracture (hazard ratio (95% CI) = 2.52 (1.05, 6.05), P = 0.039) (Table 3, Figure 2).
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We subsequently produced a CHV-BAC vector with an intact TK gene in which the bacterial genes and the antigen expression cassette were inserted into this GC-rich locus.
Except for the 3rd codon position of the Cytb locus, GC content showed little among clade variation.
The allelic variants and robust paternal effect for the Gct4 CA GC tumor susceptibility locus was subsequently applied to a male progeny testing scheme to refine the Gct4 candidate gene region.
In this GWAS analysis, we found and replicated conclusive evidence that variants in GC, the NADSYN1/DHCR7 locus and CYP2R1 that encode the vitamin D carrier protein and enzymes in the vitamin D metabolic pathway are associated with circulating 25(OH D levels, with the latter two genes representing novel findings.
Naskapi and Montagnais families segregating for albumin Naskapi give evidence for close linkage of the Gc and albumin loci with a high probability.
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