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Increasing concentrations of unlabeled VBP1, VBP3, VBP15 or high-affinity ligand controls (triamcinolone, spironolactone, 17-β-Estradiol, methyltrienolone or Promegestone) were added and the percent binding of radiolabeled ligands determined to gauge the affinity of the unlabeled competitors for the steroid receptors.
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In an effort to gauge the potential for off-target effects of these compounds, the binding affinity (Ki values) of DBeQ, ML240, and ML241 were determined for a panel of 43 CNS-relevant receptors and targets.
This would also help gauge the demand.
How should we gauge the threat?
We went down to gauge the mood.
Gauge the situation.
Gauge the situation before you automatically grin.
But gauging the noise has proved difficult.
"Walt gauged the footballs himself.
One is gauging the refusal rate.
Next, we tested how the receptor mutations change binding to IFN- γ and these ΔΔ G gauge the change of affinity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com