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Trained data collectors at each site participated in the acquisition of requisite data.
AMB and AAR conducted the gathering of data and performed all the data analyses.
In order to develop in vitro methods as an alternative to P450 animal testing in the drug discovery process, two main requisites are necessary: 1) gathering of data on animal homologues of the human P450 enzymes, currently very limited, and 2) bypassing the requirement for both the P450 reductase and the expensive cofactor NADPH.
Those numbers have been difficult to estimate because of complexities in assembling the requisite data [6] [8].
HBH and AG were responsible for gathering of the data.
N.Z was responsible for gathering of the data.
No structural gathering of those data was used.
TFC aided in study design, gathering of clinical data, data interpretation, and manuscript editing.
We also thank the general practitioners of the Belgian Sentinel Network for the gathering of the data.
AL aided in study design, gathering of clinical data, and manuscript editing.
PLN aided in study design, gathering of clinical data, and manuscript editing.
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