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Since the worst tides come mostly in winter, Dr. Ammerman and Dr. McClennen wrote last week in Science, gate closure "will end up taking place repeatedly, day after day and week after week".
Nevertheless, the results from these observations associated older adults and elderly with crossing during gate closure and with afternoon peak hours.
Interestingly, pyrabactin binds to PYL3 in a distinct nonproductive mode with gate closure, which sheds light on the design of agonists and antagonists for abscisic acid receptors.
Loss of selectivity has been associated with gate closure occurring at the outer part of the pore in K2P channels and is thought to occur by what has been termed collapse of the selectivity filter [23].
Thus the gate closure is a conformational change in PilQ.
That is, do the authors think that the "gate closure" is a conformational change in PilQ itself or rather a redistribution of another protein?
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Additional information concerning protest activities, to include any gate closures, changes to Force Protection Condition, excepted traffic delays, etc., will be distributed via a MCBQ FROSTCALL later this week.
The development of the mitre lock, a double-leaf gate the closure of which formed an angle pointing upstream, heralded a period of extensive canal construction during the 16th and 17th centuries.
More recent progress has provided strategies for controlling the gate's closure using chemical agonists or protein engineering approaches.
Nevertheless, it appears that the two gates are tightly coupled and in many Kv channels opening of the lower gate triggers closure of the upper gate in a process known as C-type inactivation (Yellen et al, 1994).
Third, activation of the channel by the Ct mutant E306A stabilizes the C-type gate to closure by extracellular pH and this effect is reversed by combination of E306A with the Ct decoupling triple glycine mutant.
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