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In our case, at least two distinct types of GCs, namely a gastric type and a Lauren's intestinal type, were identified by gastrectomy and ESD, respectively.
The morphologic features of this tumor differed from those of the first and second tumors; this one was diagnosed as being of gastric type.
Previous studies with a smaller range and number of samples revealed the specificity of this protein for gastric type epithelium and the absence from other normal epithelia.
The majority of patients were male (62.5%) and had colorectal or gastric type cancers (81.3%); all patients were Asian (Japanese).
Barrett's metaplasia of gastric type is characterised by the presence of columnar cells resembling the gastric foveolar ones (Zwas et al, 1986).
In IPMN's of the pancreas, MUC4 may enable a differentiation between malignancies of the intestinal type and the gastric type 56.
Similar(45)
Abraham, S. C., Montgomery, E. A., Singh, V. K., Yardley, J. H. & Wu, T. T. Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology.
Gastric-type epithelium and islands of oxyntic mucosa in duodenal biopsies are considered by some to be part of a spectrum of metaplastic change related to peptic disorders.
The oncocytic neoplastic cells, as well as the nononcocytic cells, produced gastric-type mucin (MUC5AC and MUC6) and showed claudin18 and HepPar-1 positivity.
Interestingly, this gastric-type like AIS was also p16 negative.
Gastric-type IPMNs express MUC5AC and sometimes MUC6 (Table 1) [ 48, 49, 61].
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