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against ethanol-induced gastric damage.
In addition, both prevented indomethacin-induced gastric damage.
Gastric damage was also prevented starting at 10 mg/kg, p.o.
Gastric damage was evaluated in the absolute ethanol-induced ulcer model in rats.
Gastric damage was induced by intragastric administration of 0.2 mL of ethanol (96%).
The anti-inflammatory activity and gastric damage, however, were very weak or not detectably different from aspirin.
Although 3 shows potent analgesic effect without gastric damage, the urine after administration of 3 becomes red purple.
While the research is still preliminary, it suggests spicy food may have all kinds of health benefits ranging from boosting metabolism and preventing gastric damage to reducing the risk of heart disease and cancer.
The histomorphometric evaluation of the gastric damage at the same doses showed a significant increase in neutral glycoproteins and sulfated macromolecules.
The present study was designed to verify whether frutalin (FTL) affords gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s).
These data indicate that increasing 2-AG protects against gastric damage induced by NSAIDs, and its primary catabolic enzyme MAGL offers a promising target for the development of analgesic therapeutics possessing gastroprotective properties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com