Sentence examples for gastric challenge from inspiring English sources

These data and the ability of chronic bilateral subdiaphragmatic vagotomy to suppress gastric acid-evoked expression of c-fos mRNA [ 1] indicate that gastric challenge with HCl is signalled to the brainstem via vagal afferents.

Last, to explore if DAV132 could restore antibiotic-associated disruption of colonization resistance (CR), mice received 300 mg/kg/d of sc cefotaxime or placebo X 3 days, together with 50 mg/d or placebo of oral DAV131 (Dadapteddaptod thethe mice), followed by gastric challenge with 10 CFU of a K. pneumoniae resistant to third generation cephalosporin (C3GR-Kp).

Gastric acid challenge enhanced the expression of c-Fos in the nucleus tractus solitarii but caused only minimal damage to the gastric mucosa.

Analysis of the behavioural reactions to gastric acid challenge indicates that vagal afferent neurons play an important role in gastric acid nociception [ 3].

In view of this pharmacological profile the question arose as to whether lafutidine would be able to modify vagal afferent signalling of gastric acid challenge to the brainstem.

Since the behavioural reactions to gastric acid challenge indicate that the c-Fos expression in the NTS is a correlate of gastric acid nociception [ 2, 3] it can be proposed that lafutidine has an inhibitory effect on gastric chemonociception.

The vagal afferent signalling of gastric acid challenge is known to be inhibited by morphine [ 1], by a combination of glutamate NMDA and tachykinin NK1 and NK2 receptor antagonists [ 4] and by antisecretory agents such as cimetidine and omeprazole [ 2].

It has previously been shown that vagal afferent neurons that signal gastric acid challenge to the NTS are insensitive to the neurotoxic effect of capsaicin [ 1] and that the activation of this pathway by acid is independent of prostaglandins [ 20].

The treatment of gastric cancer is challenging because of its highly heterogeneous etiology and clinical characteristics.

The IL-17A level in MDDCs of healthy individuals and gastric cancer patients challenged with H. pylori was significantly higher than in MDDCs which were not pulsed with H. pylori.

First, immediately after acid challenge the gastric content weight was significantly higher in lafutidine- and cimetidine-treated animals than in control rats.