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Preclinical studies indicate that garlic compounds may prevent and inhibit cancer, reduce total and low-density lipoprotein cholesterol, inhibit platelet aggregation, and regulate glucose.
It is entirely possible; however, other classes of garlic compounds manifested the phenotype in our study.
In most experiments inhibition of tumour growth was established using fresh garlic extract, garlic compounds or synthetically prepared analogs.
The molecular mechanisms resulting in apoptosis after treating cells with SAMC and other garlic compounds are, however, only partly understood and further studies of this process are important.
This effect is similar to the effect of microtubule interacting drugs that are already used in cancer therapy and encourage further application of garlic and garlic compounds in cancer treatment.
In this review the strengths and weaknesses of the experiments are discussed and the outcomes are evaluated to assess the possible significance of garlic or garlic compounds for the prevention of cancer in humans.
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It does not contain any other garlic compound such as SAC or allicin.
Treatment of cells with the garlic compound diallyl disulphide had similar effects on BimEL.
The level of a specific form of BimEL (band 3 on our Western blots) increased significantly 16 and 24 h after addition of garlic extract and the garlic compound DADS.
The garlic compound DADS, which has been used by other research groups to study apoptosis (Filomeni et al, 2003; Xiao et al, 2004), was also used to study details of the apoptotic process in MDA-MB-435 cells.
It has previously been reported that the garlic compound SAMC arrested SW-480 and HT-29 cells both at G2 and mitosis (Shirin et al, 2001) and the reason for the mitotic arrest was probably disturbance of the mitotic spindle apparatus (Xiao et al, 2003).
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