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Patient-derived hiPSCs that recapitulate the complex genetics associated with many disorders of the brain, have the potential to fill a critical gap in determining both how estrogens, or altered levels of estrogens, may contribute to pathogenetic mechanism, and moreover, provide platform from which to develop more effective and safer estrogen-based therapeutics, even in a sex-specific manner.
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We evaluate the distribution of species richness and threat among freshwater species, identify centres of freshwater endemism and, using a heuristic approach, highlight key gaps in determining how freshwater conservation actions can be targeted at the most pressing cases.
Although much work has been accomplished in cross-sectional studies to determine the role of IVCCM parameters and even threshold values (18, 34 for the diagnosis of DSP, a major research gap is in determining its role in predicting the future onset of clinically relevant disease.
These data support a critical role for gap junction permeability in determining the magnitude of induced bystander effects.
PZ and YT isolated RNA and DNA, performed the 454/Roche sequencing and made libraries and prepared Figures 1, 2 and 3. SC performed all post-shotgun assembly bioinformatics aspects of the study, assisted in gap closure and in determining sequence accuracy.
Neighborhood information is also helpful in determining gap opening positions.
Also it was observed that the voltage supplied to the electromagnet and the machining gap have significant effect in determining the normal and tangential cutting forces.
Interviews with subject teachers were useful in determining gaps in availability of FP teaching resources at the institution.
Solar irradiance in and around forest gaps plays a key role in determining the snowmelt patterns that shape how forest gaps influence spring snow cover retention relative to open or continuously forested landscapes.
For work on gap junctions and their role in determining network dynamics see for example [147, 154 158].
Previous studies [23]outline the gaps in current VA methods in determining neonatal causes of death and our results also suggest physicians using VA data have greater difficulty in coming to a common cause of death in neonates than in older children.
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