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The abnormality can increase the risk of heart attack, stroke, miscarriage, gallbladder dysfunction and toxemia of pregnancy.
Avoiding obesity to begin with, or shedding pounds through diet modification and increased exercise, can prevent gallstone formation and reverse gallbladder dysfunction.
This study was designed to determine whether a muscle defect could explain this gallbladder dysfunction.
For example, the HPO-term Gallbladder dysfunction (HP 0005609) has as alt_id the ZP-term abnormal ly) decreased functionality gall bladder (ZP 0004170).
At the safety follow-up, two patients had ongoing grade 1 gallbladder disorders, specifically gallbladder dysfunction and gallbladder wall thickening, with the latter prompting a dose reduction.
While we hypothesized both HBV and HCV would lead to reduced MeHg elimination into bile, the EH cycle can also be accelerated by liver and gallbladder dysfunction reducing uptake into hepatocytes or altering metabolism [ 18].
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These findings suggest that oridonin could reduce mitochondrial membrane potential and induce mitochondrial dysfunction in gallbladder cancer cells.
In acute acalculous cholecystitis, however, remote infection (50% of patients had sepsis or pneumonia) may have led to decreased perfusion, to ischemia, to impaired regenerative capacity of the gallbladder mucosa and to dysfunction leading to cholecystitis.
Neurogenic dysfunction of the gallbladder may create an increased intracystic pressure that is thought to be responsible for the formation of Rokitansky-Aschoff sinuses [ 3].
In particular, it may be hypothesized that dysfunction in the liver and gallbladder, key organs in the EH cycle, may contribute to the wide variability in MeHg half-life observed (from 32 to 189 days) [ 17].
Gastroparesis may also be associated with dysmotility of the esophagus, gallbladder, and biliary tract, and with pancreatic exocrine dysfunction and nocturnal diarrhea.
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