Unlike garden-variety weight gain, severe obesity generally occurs in the context of diverse hardships.
Features of hypercortisolism include weight gain, severe fatigue and muscle weakness, high blood pressure, depression, cognitive impairment, purplish skin striae, hyperpigmentation, loss of libido, impaired glucose metabolism, hirsutism, acne, and menstrual disorders [ 33, 34].
Indeed, both mouse models, which shared the same mixed genetic background, were characterized by short lifespan, reduced weight gain, severe megalencephaly and ventricular enlargement, increased cortical thickness, cortical lamination defects, hippocampal alterations, hypomyelination, and spontaneous epilepsy.
Fraker and colleagues [ 40] reported that reduced food intake, decreased body weight gain, severe interstitial pneumonitis, periportal inflammation in the liver, and increases in the weights of the heart, lungs, kidney and spleen observed in TNF-α-treated animals reverted to normal levels when insulin was administered concurrently.
Five subjects discontinued prematurely due to adverse events; two in the CIN group with significant weight gain, and 3 in the SV group with significant weight gain and severe tremor.
Expected costs and outcomes were used to estimate a total cost, total life-years gained, total severe and non-severe exacerbations and total quality adjusted life-years (QALYs) gained per patient.
Based on clinical trials, Januvia was less likely than other oral antidiabetes drugs to cause weight gain or severe drops in blood sugar.
FTT can be defined as a condition characterized by a poor weight gain or severe weight loss.
3 We also found that harms (weight gain and severe hypoglycemia) occurred less often for patients receiving long acting versus intermediate acting insulins.
The use of vildagliptin in combination with metformin has been reported to be well tolerated, with no reports of weight gain or severe hypoglycemia [ 35].
