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Jouhl's soprano starts off blandly, but gains in expression and fierceness for her two arias either side of the interval.
Eyes shine, the voice gains in expression, a sense of excitement and of being alive exists.
It is likely that all of these factors work in concert to promote a migratory and EMT-like phenotype, and that small gains in expression of a number of EMT genes can contribute to a greater overall effect.
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To test the effect of the almost two-fold gain in expression on the immune response, we created DNA vaccines from each of the sequences.
These preliminary findings suggest that loss and gain in expression of adhesion molecules is not an aberrant variation but rather an adaptive cellular and molecular mechanism of the cancer that contribute to its metastatic ability.
As a further confirmation of the CpG island microarrays, we identified seven clones whose methylation profile predicted their loss or gain in expression with disease progression by analyzing our methylation data in conjunction with Wu et al.'s expression data.
The EMT contributes to the disassembly of tight junctions and loss of apical-basal polarity in IECs due to a repression of the transmembrane adhesion receptor E-cadherin and a gain in expression of the mesenchymal features.
The acquisition of the mesenchymal phenotype is accompanied by cadherin switching (loss of E-cadherin and activation of N-cadherin), which is driven by transcriptional regulators of E-cadherin, including SNAIL and TWIST, as well as post-transcriptionally active microRNAs (for example, the miR200 family), and the gain in expression of mesenchymal markers, such as vimentin.
Overall, the losses in gene expression are both greater in number and magnitude compared to the gains in gene expression in MM samples.
By selecting female parents for long rhizomes and male parents for fertility, considerable gains in rhizome expression, survival and yield were made.
Moreover, β-catenin lower expression associated with gain in Slug expression predicts a subgroup with worst outcome (P=0.001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com