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And it is during this co-evolution that the code (possibly even expanded compared to its initial complementary core shown in Figure 1B) continued gaining specificity (see also [ 3, 11, 22, 32]).
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To gain specificity, selective precleaning and elution protocols were developed for efficient discrimination between specific and nonspecific or less-specific binding proteins.
One approach is to study the expression of receptors to gain specificity.
In SARS coronaviruses, the spike is able to retain specific binding affinity for the ACE2 of more than one host species, and rapid evolution to gain specificity for novel ACE2 species has been demonstrated [42], [43].
Analyzing the structure of the spike-receptor complex is essential to understanding how viruses can adapt to utilize receptors from different species and how they may evolve to gain specificity for new receptor types.
Immune and functional pressures will remain during the whole process of both differentiation and maintenance of a gained specificity.
PP2A controls the phosphorylation level of a wide range of substrates and is believed to gain specificity through utilization of a plethora of particular targeting regulatory subunits [ 13].
To gain specificity for hDAAO inhibition, we sought compounds that combined elements of both the D-amino acid and the flavin portion of the FAD cofactor.
To gain specificity, these nonpersistent chemicals, such as chlorpyrifos and many volatile organic chemicals, have been measured as the parent compound in blood (Needham 2005; Whyatt et al. 2004).
Another way to gain specificity and increase the time window for the exposure assessment for certain nonpersistent chemicals is to measure their reaction products or adducts, such as with hemoglobin, albumin, or DNA.
From Fig. 1 we can see the improvement of our refinement algorithms over the base algorithm is significant: RefineML improves significantly both sensitivity and specificity, while RefineFast loses a little sensitivity while gaining more specificity for sparse networks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com