In the hESC samples altogether 6248 genes were detected to be gained, of which 1866 genes had a significant association between the CNV and expression.
We estimate incremental cost per life year gained of £12 800–£17 600, which reduces further if long-term benefits are considered.
To gain intuition of which features may have a bigger influence on the results, the performance of each individual feature was evaluated independently.
It is a priority better suited to allegory and treatise and veiled self-flagellating confession than the profile or essay, forms in which, as Malcolm most of the time knows very well, the reader's enjoyment is reliant on small-scale acts of unavoidable truth-slighting and strategic trust-gaining, of which it is pointless in two senses to keep count.
Surely, a far better idea would be for the government to radically simplify the IHT system and phase out the plethora of reliefs, the gains of which seem to be accrued largely by the very wealthiest.
Moreover, several nonlinear audio effects include amplifiers, the gain of which is automatically controlled by the level of the input signal [11].
In total we attempted validation on 20 novel cnD gains, of which five were confirmed to be amplified relative to C57BL/6J.
The c-myc gene is located on chromosome 8q, the gain of which is an early event in prostate carcinogenesis (Alers et al, 2001).
By using high resolution array CGH, two copy number gains (of which one amplification) and 5 losses were detected at the 12p12.1 locus where KRAS is localized (Additional file 2: Figure S2).
The mutations could result in a toxic gain-of-function, which could be either misregulation of its normal function or acquisition of a novel toxic function.
Soon afterwards, p53 mutants were found to have gain-of-functions, which explain some oncogenic phenotypes of mutated p53 cDNAs [ 10].
