Sentence examples for gaining activity from inspiring English sources

Instead, we found that many nef alleles of X4 SIVsmm strains were unable to downmodulate TCR-CD3 and to suppress T cell activation, while maintaining all other functions and even gaining activity in downmodulating CXCR4.

The kinase genes gaining activity in prostate cancer were associated with DNA replication, cell cycle control, mitotic chromosome handling and regulation of cell growth.

Among the 37 kinase genes gaining activity in PRCa in comparison to healthy prostate there were 22 kinase genes (MASTL, CCRK, NEK6, MAP3K13, DCLK1, CSNK1G3, ATR, SBK1, TESK2, BRSK2, FGFRL1, VRK1, PRKCZ, PKN2, LMTK3, CDK3, NRBP2, MAP4K3, MARK1, MARK4, TSSK4, ENSG00000121388) without previous association to PRCa based on the Pubgene [52].

We know that bacterially expressed protein displayed the odd characteristic of gaining activity upon being stored at 4 °C, consistent with slow structural rearrangements.

In contrast, endomorphin-1 gained activity with Y328F but lost activity at W320A, in both pathways.

Epigenetic marks associated with evolution of the human cortex gained activity relative to those in mice and monkeys.

Medicinal chemists will immediately have ideas how to alter a given structure in order to gain activity.

An inactive atromentin synthetase, InvA3, gained activity after a domain swap that replaced its native thioesterase domain with that of InvA5.

By repairing the hydrophobic defects, the peptide (17BIPHE2) gained activity against the ESKAPE pathogens, including Enterococcus faecium, S. aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter species.

In addition, MALT1 requires dimerization to gain activity [ 67] and the structures both revealed an antiparallel caspase-like dimer along β6.

Similarly, when Cry4Ba loop 3 was replaced with a Cry4Aa-loop 3-mimic peptide, the engineered Cry4Ba gained activity against C. pipiens, which was originally resistant to Cry4Ba [ 30].