In addition to gaining motility and invasiveness, tumor cells that undergo EMT also acquire increased resistance to many traditional cancer treatment modalities, including chemotherapy and radiation.
The immotile testicular spermatozoa are gaining motility through slow passage through the epididymal tubules.
In addition, increases in α-sma and the cytoskeletal rearrangement provide tools for gaining motility.
EIEC manipulates the cytoskeleton for invasion of a host cell and/or to gain motility in the cell.
As cells undergo EMT, they lose their epithelial features including sheet-like architecture, polarity and E-cadherin expression and gradually gain motility and expression of mesenchymal markers such as N-cadherin, fibronectin and vimentin.
Furthermore, there is a quantifiable increase in cellular dynamics with PGCs gaining motility, and their migratory ability does not depend on the formation of specific interactions with other cells or the extra-cellular matrix, as revealed by in vitro migration assays.
However, further analysis is needed to probe the reason for retention or loss of flagellar genes in the Sphingobium strains, and to investigate whether Sphingobium have the potential to gain motility through acquisition of the remaining genes under the high selective pressure of HCH in the stressed environments.
Spermatozoa gain motility during ejaculation as pH and bicarbonate concentration increase during mixing of sperm and seminal plasma [ 33].
It is only after their travel in the epididymis that sperm gain their motility and fertility.
The integrin complex represented in module 40 signifies the effort of tumor cells to gain the motility and invasiveness.
First, gain in motility and invasiveness is essential for most steps in metastasis (the initial step, intravasation, and extravasation).
