Exact(8)
These neomorphic mutations result in the gained function of converting α-KG to 2-hydroxyglutarate (2-HG), an oncometabolite.
RTL1, also known as PEG11, has evolved from an ancestral gypsy LTR- retrotransposon insertion prior to the divergence of marsupials and placental mammals and has gained function in the mammalian genome [32], [33].
Once the epithelial tissue has gained function, the epithelial tissue is subjected to experimental protocols relevant to our research program (ciliary mediated mechanosensation).
However, despite its minor localization at the late Golgi, we cannot discard the possibility that GeaA1 would have gained function at this compartment.
TGF-β131 gained function in this assay so that it induced migration similar to TGF-β3, while TGF-β313 lost function and thus does not induce migration, similar to TGF-β1.
In contrast, although the series of β-carbon-substituted carboxylic acids, including, for example, compounds 26 and 29, also gained function at the C4.57G mutant (Fig. 7 E, F), these compounds were substantially less potent at hFFA2-C4.57G hFFA2-C4.57G2, suggesthan that additional residues bFFA2esuggesting likely thatontribute to this additionalthe bFFA2 ligand SAresidues
Similar(52)
Transcription is necessary for a protogene to gain function and be selected upon.
The morphologies of these architectures are adjusted to gain functions via structural control at different dimensions.
As such, certain genes need to gain functions and activate critical pathways.
However, if the system needs a generic selection, gain functions or statistical test is chosen (specifically Chi squared).
Figure 2 A directional antenna gain function.
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