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We then asked whether the promoters of genes that lost or gained correlation with pfcrt exhibited distinct histone acetylation profiles.
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We identified modules which lose or gain correlation between the disease states using the coXpress R package for differential coexpression analysis [ 37], modified to perform the analysis on pre-defined clusters.
Genes that gained positive correlation had higher levels of the acetylated histone H3K9ac in their promoters while those that gained negative correlation had lower levels of this histone modification compared to the genome baseline.
A transcript was considered to gain a correlation to pfcrt if the correlation in CQR but not CQS was significant and a loss of correlation if the correlation was significant in CQS but not CQR strains.
It seems unlikely, nevertheless, that na happens to gain a correlation with the successive geomagnetic jerks.
This method of analysis accounts for the nonindependence of students' scores within a classroom and uses appropriate degrees of freedom for testing teacher gain correlations with student gains.
In the absence of ancillary information on gene gain correlations, the assumption of random independent gains provides a useful null model.
A positive correlation would be, for example, because of additional resource consumption in life years gained; a negative correlation would be, for example, because of less resource consumption in cured subjects.
The advantage gained through the correlation receiver is called spreading gain, while the non-cooperative receiver can rarely benefit from it.
The final step is to divide the remaining objectives into two conflicting groups based on their newly gained Spearman rank correlation coefficients.
Using a biclustering analysis and post-processing, we efficiently identified large number of gene sets that gained or lost correlation under all or specific combinations of brain diseases compared to the normal conditions.
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