Sentence examples for gained activity from inspiring English sources
In contrast, endomorphin-1 gained activity with Y328F but lost activity at W320A, in both pathways.
Epigenetic marks associated with evolution of the human cortex gained activity relative to those in mice and monkeys.
An inactive atromentin synthetase, InvA3, gained activity after a domain swap that replaced its native thioesterase domain with that of InvA5.
The structure activity relationship revealed that, besides better engaged SAAM binding by the MAT mutants (lower Km value in contrast to native MATs), the gained activity toward the bulky SAAMs stems from their ability to maintain the desired linear SN2 transition state (reflected by higher kcat value).
By repairing the hydrophobic defects, the peptide (17BIPHE2) gained activity against the ESKAPE pathogens, including Enterococcus faecium, S. aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter species.
Similarly, when Cry4Ba loop 3 was replaced with a Cry4Aa-loop 3-mimic peptide, the engineered Cry4Ba gained activity against C. pipiens, which was originally resistant to Cry4Ba [ 30].
It is therefore conceivable that, during evolution, eIF5A gained activities in addition to its primary role in translation elongation, such as the promotion of cytoplasmic accumulation of specific transcripts (Hauber, 2010).
Instead, we found that many nef alleles of X4 SIVsmm strains were unable to downmodulate TCR-CD3 and to suppress T cell activation, while maintaining all other functions and even gaining activity in downmodulating CXCR4.
Medicinal chemists will immediately have ideas how to alter a given structure in order to gain activity.
The kinase genes gaining activity in prostate cancer were associated with DNA replication, cell cycle control, mitotic chromosome handling and regulation of cell growth.
We know that bacterially expressed protein displayed the odd characteristic of gaining activity upon being stored at 4 °C, consistent with slow structural rearrangements.
