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While beneficial in reducing body weight gain, vaccination against GIP, a self-antigen, may raise concerns associated with the induction of auto-immune reactions.
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a Costs are excluding vaccination costs b Undiscounted c Discounted In addition to the health gains, vaccination also prevents approximately €6.3 million of direct and €1.3 million of indirect costs.
On the other hand, given a cost-effectiveness threshold on 50,000 € per QALY gained vaccination of boys and girls is estimated to be cost-effective.
The balance sheet listed: 1) major health conditions associated with measles; 2) the risk among the unvaccinated who contract measles; 3) the risk among the vaccinated; 4) the risk difference between vaccinated and unvaccinated; and 5) the likely net gain from vaccination for each condition.
It is possible that vaccines B and C had a positive effect on weight gain after vaccination as previously reported [ 25].
Immunity is gained through vaccination with the vaccine distribution considered a control variable.
19 In addition to life years gained we also calculated QALYs gained by vaccination.
The cost per QALY gained of vaccination is insensitive to vaccine coverage in girls over the range explored 70-900%).
This model does not include any such gains and therefore could underestimate the total utility gained from vaccination.
Modelled on estimates where the vaccine had greater efficacy, the gains from vaccination would be more substantial.
Several studies have described how behavioral reversals could mitigate the gains from vaccination or even produce perverse outcomes where the use of the vaccine results in more infections [8], [37] [39].
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