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Unlike garden-variety weight gain, severe obesity generally occurs in the context of diverse hardships.
Features of hypercortisolism include weight gain, severe fatigue and muscle weakness, high blood pressure, depression, cognitive impairment, purplish skin striae, hyperpigmentation, loss of libido, impaired glucose metabolism, hirsutism, acne, and menstrual disorders [ 33, 34].
Indeed, both mouse models, which shared the same mixed genetic background, were characterized by short lifespan, reduced weight gain, severe megalencephaly and ventricular enlargement, increased cortical thickness, cortical lamination defects, hippocampal alterations, hypomyelination, and spontaneous epilepsy.
Fraker and colleagues [ 40] reported that reduced food intake, decreased body weight gain, severe interstitial pneumonitis, periportal inflammation in the liver, and increases in the weights of the heart, lungs, kidney and spleen observed in TNF-α-treated animals reverted to normal levels when insulin was administered concurrently.
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Most importantly, the Aβ42 K16N peptide alone is almost non-toxic and only gains severe toxicity when it is mixed with its wild-type (WT) counterpart.
We did not consider three outcomes included by Gui et al (congenital malformations, cord pH, and phototherapy), 17 but we considered nine additional ones (maternal total weight gain and severe hypoglycaemia, induction, cord C peptide and insulin, Apgar score at 1 minute, macrosomia, severe neonatal hypoglycaemia, and mortality (stillbirth, neonatal, perinatal)).
Based on clinical trials, Januvia was less likely than other oral antidiabetes drugs to cause weight gain or severe drops in blood sugar.
FTT can be defined as a condition characterized by a poor weight gain or severe weight loss.
3 We also found that harms (weight gain and severe hypoglycemia) occurred less often for patients receiving long acting versus intermediate acting insulins.
The use of vildagliptin in combination with metformin has been reported to be well tolerated, with no reports of weight gain or severe hypoglycemia [ 35].
The proportion of patients achieving A1C ≤7.0% without weight gain or severe hypoglycemia at week 24 was the primary end point.
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