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In contrast, the second category (type II TLR9-expressing cells) includes primarily follicular B cells in mice (and possibly colon epithelial cells and naïve B cells in humans) that directly respond to single stranded CpG-DNA, whereas they require additional co-signals to gain responsiveness to more complex CpG-DNA.
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Following the removal of the anti-differentiative signal, LIF, cells gained responsiveness to BMP4 and Wnt3a as mesendoderm inducing signals between d1.5 and d3, at a time corresponding to their upregulation of epiblast associated genes, such as FGF5 [2].
DA administered in ovo induces acute neurotoxic effects as the brain matures and gains responsiveness to the toxin.
This is the only way to optimize and sustain health gains, ensure responsiveness to client expectations and guarantee fairness in financial contributions to health service expenditures.
To gain insight into responsiveness, the Standardized Response Means (SRM) with corresponding 95% CIs were calculated for each subscale of the FAOS.
This possibility then leads to the question how often innovation, defined as gain of stress responsiveness from a non-responsive ancestral gene, occurred in green algae.
Epigenetic control of LIF receptor expression by histone acetylation can account for the gain of LIF responsiveness.
Their gain or postsynaptic responsiveness can be altered by several factors including fast synchronous oscillatory activity and/or neuromodulators such as acetylcholine and dopamine, both of which are implicated in attentional mechanisms (Feldman and Friston, 2010).
However, we also contend that responsiveness gains through PCA can diminish with product complexity and can increase operating cost.
Although the role of immune marker secretory immunoglobulin A (SIgA) in stress-related health outcomes is gaining recognition, SIgA responsiveness to acute stress has rarely been assessed in adults, and not at all in children.
For large and complex organizations, gaining momentum and responsiveness can be an exercise in futility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com