Interestingly Cluster 4, which had the higher rates for rapid cycling, eventually gained remission.
To gain complete remission of clinical symptoms, the tumor must be completely removed.
Casquero et al. [13] reported that among 12 patients who were given rituximab, 9 gained complete remission and 3 died of primary disease.
Positive expression, either if primarily present or later acquired, was associated with melanoma progression, whereas patients primarily negative or with subsequent loss gained clinical remission or stable disease, even if in advanced stages (p < 0.005).
In 1452, during the posthumous investigation into her execution, the Church declared that a religious play in her honor at Orléans would allow attendees to gain an indulgence (remission of temporal punishment for sin) by making a pilgrimage to the event.
Patients who gained a complete remission (CR) or good partial remission (GPR) were then randomised between two further cycles of PVACEBOP chemotherapy, or an autologous haemopoietic stem cell transplant (HSCT) with etoposide and melphalan preconditioning.
This lead to the concepts of mucosal healing and deep remission gaining acceptance as the more desired goals for therapy within an ambitious disease-control therapeutic approach, namely, treat-to-target strategy.
In CD, only one third of patients with corticosteroid-induced clinical remission gained normalisation of the endoscopic changes [ 50], whereas in UC, this correlation is known to be closer [ 51].
The analysis suggests that patients treated with Mezavant are in remission longer, gain more QALYs, and incur lower direct costs to the SHI compared with patients receiving Asacol.
However, even in JIA patients the lag time in which to gain optimised case with disease remission or low disease state can take time and in that time joint and soft-tissue damage can occur.
Utilities for acute EPS and weight gain were calculated by multiplying the remission utility value by the expected decrement in utility reported by NICE (0.888 for acute EPS and 0.959 for weight gain) [18], which was estimated from the number of people endorsing the presence of each side effect, as reported in a paper by Lenert and colleagues [28].
