Overall, the 16/22 and SA/Mock treatments resulted in a loss of genome size, whereas the 28/22 resulted in a net gain of genome size (supplementary table S1, Supplementary Material online).
Seven patients reached a TS from −100% to −60%, 20 patients from −59%to−30%39 39 patients reached from −29% to 0% and 15 patients gained tumour size from 1 to 19%, while 19 patients initially had a gain of tumour size of ⩾20% or occurrence of new lesions.
A hundred patients were stratified into five subgroups according to their change of tumour size with first treatment evaluation: −100% to −60%−59%to−30%and−29% −29% to 0% TS or gain of tumour size from 1% to 19% and ⩾20% or occurrence of new lesions (i.e., progressive disease).
A gain of that size might typically come in a year.
But in the last 50 years they've scored a net gain of that size only twice, in 1974 and in 2006.
He says part of this can be attributed to loss aversion, the human tendency to dislike a loss more than they like a gain of equivalent size.
On any other day, a gain of that size would go unheralded, but not after the turmoil that began in late 2008 and persisted through a sluggish recovery.
For a gain of that size, Democrats would need to get a victory by their only embattled incumbent, Charles S. Robb of Virginia; take four out of five open seats (in Florida, Nebraska, Nevada, New Jersey and New York) and then defeat five out of the nine more or less vulnerable Republicans, in Delaware, Michigan, Minnesota, Missouri, Montana, Pennsylvania, Rhode Island, Vermont and Washington.
The authors call for an approach based on two ideas (both mentioned on earlier occasions in this space): loss aversion and mental accounts.Loss aversion is the idea that people feel the pain of a loss more acutely than the pleasure of a gain of equal size: changes in wealth, and their direction, are what count, regardless of levels.
