Sentence examples for gain of functional from inspiring English sources
In many human tumors, including epithelial ovarian cancer [23], [25], [26], [27], [28], [29], [30], PIK3CA activation is a critical oncogenic event and can be mediated by multiple genetic/genomic alterations such as gene copy number amplification [23], gain of functional mutations [24], and transcriptional up-regulation [33], [34], [35].
The second pattern was that represented by sites (23.44%) that were variable in GroEL1 and GroEL2 and became conserved in GroEL3 (indicating a gain of functional constraints in GroEL3 as the most parsimonious hypothesis).
The absence of a strong correlation between heteropecilly and heterotachy makes sense because the two heterogeneities do not apply on the same criteria: heterotachy is mainly due to loss or gain of functional constraints (i.e. variable strength of constraints), whereas heteropecilly is rather due to variation in the nature of functional constraints, not in their strength.
We know from other angiosperm mitochondrial genomes that sequence transfer from the plastid genome is frequent on an evolutionary timescale [ 14, 55] and that on occasion these transfer events led to the gain of functional tRNAs, based on their widespread conservation across angiosperms [ 56].
Second, the 293 cells have relatively lower SALL4 expression compared to blood cell lines, which is better to demonstrate the gain-of functional study.
Much of the current knowledge has been informed by targeted gene deletion experiments and gain-of-functional analysis.
Changes in splicing patterns can affect biological processes by many different mechanisms, including gain-of-function or functional switches, altered cellular localization, dominant negative effect, changes in protein/mRNA stability.
Here, we describe a battery of mutagenic cassettes that can be applied in conjunction with transposon vectors to mutagenize genes, and highlight versatile experimental strategies for the generation of engineered chromosomes for loss-of-function as well as gain-of-function mutagenesis for functional gene annotation in vertebrate models, including zebrafish, mice, and rats.
Here we test the utility of combining a whole organism RNA-seq approach with mab-5 loss and gain-of-function mutants and functional validation using RNAi to identify genes regulated by MAB-5 to control Q descendant migration.
The annual genetic gains of functional traits are either positive or at least the negative trend can be reduced.
Combining aerobic with resistance training, alternating the training each session can be an important alternative to preserve gains of functional capacity and muscle strength status.
