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In the case of substitution of the acid with an acylsulfonamide, we observed a complete loss of activity (15 versus 25), maintenance of inhibition (16 versus 26), and significant gain of efficacy (17 versus 27).
It is tempting to speculate that partition of the CCR4 or POP2 functions in the course of evolution has been positively selected as resulting in a gain of efficacy.
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Several aDBS parameters, including the level of smoothing of beta activity to be applied and the target level of on-stimulation time, remain to be optimized, so that the gains in terms of efficacy and efficiency seen here may be further improved in time.
We did not observe any relationship between risk for CSDIs and response to therapy (as measured by CD4 count and weight gain) but these measures of efficacy are insensitive, do not correlate tightly with HIV viral load, and were missing in over a quarter of our patients.
Thus, these algorithms favor the use of glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors because of their efficacy and safety, include thiazolidinediones (TZDs) as "well-validated" agents, and move sulfonylureas (SFUs) to lower priority because of their risk of hypoglycemia, weight gain, and short period of efficacy [ 24].
This is important because the synaptic gain or efficacy of coupled neuronal populations determines the form of their spectral (oscillatory) behaviour.
Implants in particular have gained prominence with evidence of efficacy including both dexamethasone and fluocinolone loaded devices.
NDLM will yield considerable efficiency gains, since the estimate of efficacy at a given dose will be informed by that at neighbouring doses.
In each case, the COMACS study data suggested that this targeted control would be gained at the cost of efficacy at other point(s) during the day.
[#unhandled_cartoon] Alessandro Monsutti, an anthropologist who has studied the Hazaras, fears that the short-term gain of the Hazara units' efficacy may be outweighed by long-term harm.
Alessandro Monsutti, an anthropologist who has studied the Hazaras, fears that the short-term gain of the Hazara units' efficacy may be outweighed by long-term harm.
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