Sentence examples for gain interactions with from inspiring English sources

Starting from a previously described nanomolar inhibitor of AmpC β-lactamase, three new inhibitors were designed to gain interactions with highly conserved residues, such as Asn343, and to bind more tightly to the enzyme.

Collectively, these results suggest that the second UBA in USP13 inhibits its DUB activity, but at the same time allows it to gain interaction with gp78.

Because multiple microtubule ends attach to a human kinetochore, it is likely that end-on conversion is a multistep and gradual process wherein a kinetochore progressively loses contact with microtubule walls as it simultaneously gains interaction with microtubule ends.

According to this model, all proteins gain new interactions with a rate that preferentially increases with the number of interactions (the rich get richer).

Purely anecdotal evidence we have gained through interactions with dozens of prospective students every week also appears to negate the impact of the London Met case.

Based on this premise, we initiated the present study to explore whether higher affinity TCRs generated through mutations in these CDRs or other regions would lead to significant reductions in peptide specificity (i.e. the result of greater binding energy gained through interactions with major histocompatibility complex (MHC) helices).

Nevertheless, Et gains stacking interactions with W61 and van der Waals contacts with S86, M116 and N154.

Let us assume that a single protein gains new interactions with newly emerging proteins at the rate f0 ξ0/ N, where ξ 0 is the degree of an entirely new protein and N is the total number of interacting proteins.

For more complicated model of evolutionary gene duplication events, the probabilities of lost and gained interactions will be related with the network structure.

Furthermore, we demonstrate that loss or gain of interaction with lamins changes the subnuclear position of several interacting genes, but per se is not sufficient to change their gene expression levels.

In addition, it remains unclear which type of allogeneic block graft represents the most reliable one by means of bone gain and interaction with host bone.