Sentence examples for gain in efficacy from inspiring English sources

Increasing their dose would not lead to a gain in efficacy when the plateau is reached [23].

The gain in efficacy from generating a mixture does not depend on the diversity of the immune response.

If the increase in efficacy or the proportion protected is expressed in equivalent immunogenicity, the gain in the proportion protected is approximately twice the gain in efficacy.

Conservation efforts aimed at enhancing the regeneration of endangered plant-disperser systems may gain in efficacy by manipulating the spatial distribution of dispersers (e.g. through the creation of refuges and feeding sites) to create areas favourable to plant recruitment.

Conservation efforts aimed at enhancing the regeneration of endangered plant populations in the Mediterranean basin, particularly at the micro-scale [41], [42], may gain in efficacy by incorporating spatially explicit predictions of plant recruitment such as presented here.

For example, the gain in efficacy by mixing two immunogens each of which give a mean 50% efficacy and for which the responses are independent, is equivalent to improving the immunogenicity of a single component by 3.8 fold (Fig. 3b, binary mix, fold range 65) with a corresponding increase in efficacy from 50 to 75%.

Several controlled trials as first- or second-line therapy have started recently and over the next few years we should learn whether this approach will provide significant gains in efficacy.

This study predicts that under optimum conditions, useful gains in efficacy and in the proportion of responders in a community can be obtained through the use of vaccines containing mixtures of immunogens targeting a single pathogen.

In conclusion, after optimizing immunogen choice and formulation, significant gains in efficacy and the proportion of the population protected by a vaccine may be obtained by addition of further antigens targeting the same pathogen.

To provide a basis for more rational design of multi-component vaccines, we have developed a mathematical model to investigate the potential gains in efficacy generated by combination vaccines.

The model allows a comparison between the gains in efficacy from adding multiple immunogens with gains from more potent formulations or by choosing more efficacious immunogens and delineates the limited set of conditions where multi-component vaccines will be of practical importance.