Moreover, the weight of evidence of efficacy in bipolar depression resides with olanzapine and quetiapine, and that on weight gain overwhelmingly with olanzapine; extrapolation to other drugs in the class may not be appropriate in these circumstances.
The model was also evaluated using different assumptions about the utility gain from IVIG, the extrapolation of IVIG relapse rates, treatment switching for corticosteroid patients after suffering an AE, and on the dosing and frequency of maintenance IVIG treatment.
In other words, the initial L POD-based SMFEROE solutions are gained by means of projecting the initial L SMFE solutions into POD basis, while other ((N-L)) SMFEROE solutions are gained by means of extrapolation and iterating equations (38), (39), and (40).
Apart from the challenging molecular examination of cartilage characteristics in vivo, the extrapolation of data gained from animal models to the human situation in vivo is difficult, thus limiting direct conclusions.
We have demonstrated that the expression patterns of several genes encoding potato HyPRPs do not correlate with those of their Arabidopsis orthologues, pointing out the limits of extrapolation of knowledge gained by experiments in model plants towards target crop species.
As mentioned above, NOAELs usually are divided by assessment factors considering, for example, the uncertainty of extrapolation of data gained with certain test organisms in the lab to toxicity thresholds applicable for human health protection (factor = 10) and the between humans differences in sensitivity (factor = 10).
This extrapolation was performed to gain an effect of the potential costs associated with selection of the IVD test and was not intended to suggest that such costs might be saved or accrued in the US.
An extrapolation of these results gained in a cell-free in vitro setting to the clinical situation is not possible.
That is, the extrapolation allowed us to have the gain in performance from the a little bit smaller pupil, but made the results more stable over time when testing a human subject.
Six different formulations have been tested to analyze the gain introduced by each source of information: (1) horizontal interpolation, (2) vertical extrapolation, (3) extrapolation of past observations, (4) volumetric reconstruction, (5) horizontal and temporal reconstruction, and (6) volumetric and temporal reconstruction.
To gain a complete understanding of the full metabolic response requires either extrapolation about the identified paths or the further refinement of the hypothesis through explicit specification of start and end compounds.
