In this flow regime, rigid fixed wings drop dramatically in aerodynamic performance while flexible flapping wings gain efficacy and are the preferred propulsion method for small natural fliers.
Functional gain was determined by the motor FIM gain (efficacy), and the relative (to potential) functional gain was determined by the Montebello Rehabilitation Factor Score.
The following data were extracted for each recommendation: efficacy: progression-free survival (PFS) gain efficacy: overall survival (OS) gain incremental cost-effectiveness ratio (ICER) recommendation reason for negative recommendation (if applicable) arrangements between payers and manufacturers (if applicable: risk-sharing, price negotiation, access scheme).
For example, the gain in efficacy by mixing two immunogens each of which give a mean 50% efficacy and for which the responses are independent, is equivalent to improving the immunogenicity of a single component by 3.8 fold (Fig. 3b, binary mix, fold range 65) with a corresponding increase in efficacy from 50 to 75%.
One strategy to accomplish this is to selectively cripple the involved tumor resistance mechanisms, thereby allowing the affected anticancer drugs to gain therapeutic efficacy.
If it turns out that, as Wang's group suggests, in fact complement factor H must be coadministered with ADM to gain sufficient efficacy, then this represents another challenge for drug development, which we do not face with the development of a therapeutic antibody.
Increasing their dose would not lead to a gain in efficacy when the plateau is reached [23].
The gain in efficacy from generating a mixture does not depend on the diversity of the immune response.
Conservation efforts aimed at enhancing the regeneration of endangered plant-disperser systems may gain in efficacy by manipulating the spatial distribution of dispersers (e.g. through the creation of refuges and feeding sites) to create areas favourable to plant recruitment.
In the case of substitution of the acid with an acylsulfonamide, we observed a complete loss of activity (15 versus 25), maintenance of inhibition (16 versus 26), and significant gain of efficacy (17 versus 27).
Conservation efforts aimed at enhancing the regeneration of endangered plant populations in the Mediterranean basin, particularly at the micro-scale [41], [42], may gain in efficacy by incorporating spatially explicit predictions of plant recruitment such as presented here.
