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For patients with low body mass index (BMI) and/or insufficiency states, such as the elderly, caloric supplementation is helpful for weight gain, amelioration of nutritional deficiencies, and prevention of diabetic complications [ 69, 72– 72].
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Nevertheless, by using a cholesterol-rich diet rather than a high-fat diet, we minimized weight gain, preventing amelioration of the OA process via increased loading [ 41].
The restoration of gut mass achieved by exchange of cellulose for inulin correlated with amelioration in body weight gain and adiposity induced by HFD (Fig. 6 D ).
More recently and in connection with C9ORF72 expansion, a strategy based on antisense oligonucleotides directed to C9ORF72 transcript or repeat expansion induced amelioration in the C9ORF72 pathogenic gain of function and in the vulnerability to excitotoxicity in vitro [ 12].
Sitagliptin improved glucose tolerance and reduced weight gain in db/db−/− mice, which were associated with amelioration of these pathological changes in cardiomyocytes [ 114 ].
Trientine had a modest effect on the body-weight:time interaction in diabetic animals consistent with the slight amelioration of diabetes-evoked impairment of weight gain (P = 0.035, LME; Table 4).
To gain further insight in the potential molecular mechanisms involved in the amelioration of inflammation in CIA by APO866, the effect of pharmacological inhibition of NAMPT with APO866 on highly purified inflammatory cells was determined in vitro in a closed system.
Both insulin and thiazolidinediones (TZDs) are effective in the treatment of hyperglycaemia and amelioration of insulin resistance in type 2 diabetes but have side effects including weight gain and fluid retention.
Prejudice was subject to radical amelioration.
We are living in the age of malodor amelioration.
But while 'living death is not pretty, unlike dead death, it offers the hope for amelioration'.
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CEO of Professional Science Editing for Scientists @ prosciediting.com