Sentence examples for gain activity from inspiring English sources

Medicinal chemists will immediately have ideas how to alter a given structure in order to gain activity.

ALK is also among the kinases that gain activity in lung adenocarcinomas, lung carcinoid tumors and squamous cell lung carcinomas in comparison to healthy lung.

In addition, MALT1 requires dimerization to gain activity [ 67] and the structures both revealed an antiparallel caspase-like dimer along β6.

The requirement of the primer to first hybridize with the target sequence to gain activity eliminates the formation of primer-dimers and greatly reduces misamplification of closely related sequences.

In the present study, we show that SIVsmm strains that switch from R5 to X4 coreceptor usage and cause severe CD4+ T cell depletion gain activity in Nef-mediated downmodulation of X4 but lose their ability to remove TCR-CD3 from the cell surface (summarized in Figure S5).

CR = crossovers required to gain activity A/E = annealing/extension *94°C for 5 min; 40 cycles of (94°C, 30 s; 40 45°C, 5 s; 72°C for 3 s); 10 cycles of (94°C, 30 s; 50°C, 30 s; and 72°C 30 s); + 94°C 2 min, 99 cycles of (94°C 1 min, 63 67°C, 5 sec), 72°C 7 min, hold at 4°C Using Pfu polymerase, which has higher fidelity than Taq polymerase, slightly decreased the reactivation rate.

If transportation is needed to participate in GAIN activities, the county provides it.

Instead, we found that many nef alleles of X4 SIVsmm strains were unable to downmodulate TCR-CD3 and to suppress T cell activation, while maintaining all other functions and even gaining activity in downmodulating CXCR4.

In contrast, endomorphin-1 gained activity with Y328F but lost activity at W320A, in both pathways.

An inactive atromentin synthetase, InvA3, gained activity after a domain swap that replaced its native thioesterase domain with that of InvA5.

Epigenetic marks associated with evolution of the human cortex gained activity relative to those in mice and monkeys.