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Some p53 missense mutations not only inhibit wild-type p53 activity but also gain a function that wild-type p53 does not have.
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When the corresponding HF response is gained, a function that maps the LF outputs to HF outputs is constructed via LSSVR.
Mutations can alter the structure of proteins that subsequently results in affecting their functions, either by gaining a function or losing one.
For the first time, the Institute gained a functioning clinic.
It is also possible that the CTF may gain a new function by having an expanded polyQ (gain-of-function mechanism).
Alternatively, one of the duplicated genes may undergo positive selection to gain a novel function (neofunctionalization).
The fate of the duplicated genes might be loss of function, gaining a new function, or subfunctionalization [ 51].
Accompanying the diversification of insect lineages, Ubx gained a novel function in the development of hind legs.
It implies that Noxes and their physiological partners evolved simultaneously, resulting in gaining a new function.
However, the evolutionary outcome may be different if the HEG or the intron gains a function other than endonuclease or splicing activity, respectively.
(a) Photoconductive gain as a function of applied bias.
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