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I had developed a Pavlovian gag response to seeing the writer's photo by her column.
Lash even supported Ecomagination's clean coal technologies: "Five years ago, I had to struggle to suppress my gag response to terms like 'clean coal,' but I've since faced the sobering reality that every two weeks China opens a new coal-fired power plant.
For the GAG response the CD8+ T cell compartment was enhanced 4 fold in NYVAC-B-C7L in comparison to NYVAC-B (data not shown).
Further, although all macaques expressed the Mane-A*10 MHC I allele which restricts the dominant KP9 Gag response, alternative MHC alleles restricting other useful T cell responses in this outbred group could confound our data.
Prior to subjects' participation in the experimental part of the protocol, written informed consent was obtained by an investigator or research coordinator and then subjects received a screening in the clinic for gag response and nasal patency.
Preferential targeting of Gag, and the breadth of the Gag response has been correlated with superior viral control in large chronic HIV-1 cohorts, as well as in elite controllers, as demonstrated with a large cohort study in South Africa and in Tanzania [47], [48], [49].
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Gag responses were shown to contribute substantially to the higher magnitude of responses found in LTNPs.
We found that the breadth of the response narrowed as the CD4 count declined and that, specifically, the contribution of Gag responses to the overall response decreased.
However, median Gag responses after the rAd5 vector boosting were also significantly higher than after DNA (p<.001) or rAd5 (p<.001) and ranged from 28 to 797 SFC/million PBMCs.
Note that not all 155 samples contributed evaluable data: based on pre-specified filtering criteria, 5 CMV responses, 5 CEF responses and 5 HIV A Gag responses were excluded in the IAVI dataset; 15 CMV responses, 14 CEF responses and 14 Gag responses were excluded in the HVTN dataset.
Additionally, HLA-A*25 (a subtype of A10) is known to present gag epitopes [47], [48], [49], and HLA-A*26 (a subtype of A10) restricted gag responses have been also reported [50].
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