An ideal bone surrogate for ballistic testing was not identified and future work is warranted.
Future work is warranted to elucidate whether this, or an alternative mechanism, is implicated in the down-regulation of cell cycle control factors observed by us.
Considerable future work is warranted in this important topic.
It would be of particular interest to test whether similar alterations occur in other forms of trauma, but future work is warranted to fully answer this question.
As DNA damage/repair response has been implicated in the pathogenesis of vascular remodeling [ 43, 44], future work is warranted to determine whether miR-223 may also participate in this process by targeting PARP-1.
Future work is warranted to test the reliability in a narrower set of interventions, for example, those included in typical systematic reviews, or to develop the criteria further in order to achieve better consensus.
In particular, future work is warranted for the integration of additional omic levels, among which the genomic level, for example replacing our approach to the correlation used in [ 25] to identify mutations drivers in cancers, and importantly for the integration of epigenomic data, which binomial distribution strongly differs from expression data.
Despite the novelty of the use of CT images to identify specific features of body composition, future work is warranted to prospectively evaluate body composition using this methodology, accompanied by metabolic measures, to better understand the clinical implications of low muscle and fat mass.
Lastly, the primary goal of this study was to evaluate eGFR variability as a new risk factor in CKD progression in order to enhance clinical decisions by clinicians, and resources planning by policy makers/administrators; nonetheless, assessing factors affecting eGFR variability as future work is warranted.
Further, the technique appears set to become the first clinically relevant measure of in vivo cardiac pHi, although future work is warranted to characterize CA activity and the response of the HCO3−/CO2 ratio in ischaemia and other cardiomyopathies, and to improve the sensitivity and spatial resolution of HCO3− and CO2 detection.
