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Future trials will probably compare predefined different duration or discontinuation policies based on clinical response and evolution of biological markers.
The implications of advancements in technology will be examined, and the optimal design of future trials will be discussed.
Future trials will be needed to test drugs currently in development for treatment of Candida strains that are resistant to existing therapies.
The result does not mean that future trials will have the same outcome - they will each turn on the individual facts.
To date, most of these trials have involved single-agent interventions but, increasingly, future trials will test therapeutic combinations that are based on a compelling scientific rationale and testable mechanistic hypotheses.
Future trials will need to weight biomarker outcomes equal to cognitive outcomes especially when the biomarkers are linked to specific mechanisms, such as changes to beta amyloid (Aβ) deposition or brain volume.
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At present, there is no indication of this but a larger planned future trial will measure this.
We are using a usual care comparator in order that the future trial will reflect real-world effectiveness of this complex intervention.
In this feasibility economic evaluation, the data collection tools to collect resource use and costs for the future trial will be developed and refined.
Any future trial will need to account for differences in standards of practice for severe sepsis in different regions of the world [ 15, 16].
The two-armed nature of the current trial meant that questionnaire follow-up procedures were decentralised, and any future trial will utilise strengthened and centralised processes of questionnaire follow-up, to maximise questionnaire returns.
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