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Sample size must be planned carefully to ensure that the research time, patient effort and costs invested in the future trial are not wasted.
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An appropriately powered future trial is necessary to determine a potential role of amitriptyline in decreasing postoperative pain.
The sample size for a future trial is estimated to be 381 women.
The potential gain from a future trial was estimated by the EVSI; this showed that the gains in monetary terms from a future trial exceed the expected costs.
Determining how large a sample will be required for a future trial was one of the benefits of conducting the present pilot study.
If a future trial is to be conducted it should be considered to promote the trial through advertising or use of other measures to motivate potential referrers to refer more eligible participants.
No Grade 4 non-hematologic toxicity was observed in this cohort and thus the recommended dose for a future trial was determined as 50 mg/m of docetaxel and 15 mg/kg of bevacizumab.
Future trials are needed to confirm these results.
Future trials are needed to determine the optimal blood pressure target during ventilator weaning.
Future trials are being shaped by the lessons learned from prior work.
In addition, the results of clinical trials in patients and their implication for future trials are also discussed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com