Two studies deserve specific mention.
Some aspects of our study deserve confirmation in future studies.
The differentially methylated genes, both hyper- and hypomethylated, represent an epigenetic peculiarity of alcohol-related HCC and may deserve future studies to identify new possible epigenetic markers of this specific type of cancer.
The limitations of this study deserve mention and consideration for future research.
The reason why glutamine is not significantly increased in the female tumour group in our rat model is unknown and deserves future studies taking also into account that gender differences have been reported in healthy subjects in some brain areas [55].
Differential expression of TCF7L2 splicing forms with alternative exon 12 encoding for truncated protein isoforms of TCF7L2 in omental and subcutaneous adipose tissues deserves future studies.
Interestingly, the grouping of Acoelomorpha and Xenoturbellida (Figure S5) has been proposed on the basis of the ultrastructures of epidermal locomotory ciliary rootlets [28] and deserves future studies.
Whether FOXD2 could be acting as a tumour suppressor gene in MSI-H CRC deserves future studies.
The partial substrate selectivity of the 120 kDa and low MW serine proteinases contained in TES deserves future studies.
The involvement of 11b-HSD in prostate physiology deserves future studies as it has already been shown to be crucial in several clinical conditions [ 18, 19].
