The observation that all DLTs occurred in patients who had received two or more prior cytotoxic regimens may suggest that the dose of this combination may need to be refined in future studies depending on the patient population.
The impact of future studies will depend on the comparison of large datasets to validate results and must include rigorous statistical analysis.
The choice of whether to use a single or multiple enzymes for future studies will depend on the application and available resources.
Determining the extent to which low-frequency and rare causal variants are colocated within breast cancer loci already identified in GWA studies depends on future sequencing efforts targeting these well-established genes.
However, useful biomarkers for early detection and therapy are still lacking and depend on future studies.
Definitive functional conclusions about the R620W allele will depend on future studies of a knock-in mouse.
How the underestimation of PJI will affect the results of previous and future studies from the registries will depend entirely on the research question raised in individual studies.
Consequently, spatial bias on a probe test might be considered as an alternative measure in future studies as it does not depend on a well-learned escape response that may be less hippocampal-dependent and more closely approximates the dwell time that is measured on the spatial exploration task.
However, considering measurement issues (e.g. response bias increasing with age) and the versatile nature of sedentary behaviour as a distinct class of behaviours, future studies must identify target groups depending on their dominant sedentary behaviour instead of overall sitting time.
