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Similar planning and rigor in statistical inferences will probably be beneficial also to future sequencing studies.
That's a good sign that future sequencing can fill in more details, he says.
Despite these advancements, genome-wide association studies are still needed to uncover novel mechanisms underlying salt sensitivity, while future sequencing efforts promise the discovery of functional variants related to this complex trait.
The lack of significant association evidence of single variants with disease in this two-stage approach emphasizes the high genetic heterogeneity of epilepsy disorders, suggests that the impact of any individual single-nucleotide variant in this disease is small, and indicates that gene-based approaches might be more successful for future sequencing studies of epilepsy predisposition.
Originally called the Short Read Archive, the name was changed in anticipation of future sequencing technologies being able to produce longer sequence reads.
Taken together, this work provides interested researchers with a practical resource to guide future sequencing projects.
When planning future sequencing work one therefore needs to take evidence for deficiencies in past performance with a grain of salt.
As a trade-off for shorter reads, we assume that future sequencing technologies will be cheap enough to allow us to sequence to a greater depth of coverage [28].
The identification of such extensive contamination of human sequence across databases and sequence types warrants caution among the sequencing community in future sequencing efforts, such as human re-sequencing.
To aid in the design of primers and amplicons for future sequencing efforts, we plotted the variation over the length of the 16S gene for the sequences contained in the database (figure 4).
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In the future, sequencing-based discovery of low-frequency variants with higher impact on intermediate diabetes-related traits is a likely scenario and identification of new pathways involved in type 2 diabetes predisposition will offer opportunities for the development of novel therapeutic and preventative approaches.
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