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Future refinements are needed.
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The reasons for these discrepancies were discussed and issues for future refinements were stated.
Future technological refinements are needed to make this technology ready for clinical practice.
Although this study did not reveal definitive evidence of causal mutations leading to autosomal recessive CHD, a number of future directions and refinements are suggested.
The design served the current purpose of the model development i.e. to generate aggregate estimates for the population, future refinements would be needed before such models can be applied in epidemiological studies.
And clearly future refinements will be needed.
Furthermore, various other refinements are certainly possible that will be treated in future work.
This information will help determine which technical refinements are most likely to be beneficial and can guide future clinical studies.
Potential areas for future development and refinement are discussed in the Conclusions section of the paper.
One future refinement would be to purify cells from mice bearing multiple fluorescent knock-ins of different colors (e.g. SSTF1GFP|SSTF2 dsRed).
Thus a further future refinement would be to document and adjust for comorbidities and to determine whether this makes a significant difference in the predictive values.
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