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Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.
Future randomized controlled trials comparing large numbers of antibiotics in the setting of an already low infection rate are inappropriate.
Future randomized controlled trials should consider the dose of ethanol and the duration of ethanol consumption and abstention in the experimental design.
In future, randomized controlled trials (RCT) with smart and flexible design as a good approach to evaluate the effectiveness will be widely used in CM for RA clinical study, with better research methods suitable for certain CM clinical researches.
To examine the quality of evidence and the variability in the off-label use of bevacizumab (Avastin; Genentech Inc, South San Francisco, California, USA) in the treatment of retinopathy of prematurity (ROP) and to discuss the implications for the design of future randomized controlled trials.
This hypothesis generating data warrants further evaluation in future randomized controlled trials of the intervention.
Therefore, any speculation on the definition of rCM criteria useful for ONS selection [4, 7] falls exclusively on future randomized controlled trials (RCTs).
Since most studies are based on case series and case reports, it is reasonable to perform future randomized controlled trials (RCTs) on pharmacological treatments of AH.
Also, not being a controlled study, the observed safety and efficacy data need to be further evaluated in future randomized controlled trials.
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Future randomized-controlled trials with well-defined inclusion criteria are needed to fully define all of the factors contributing to flare-ups associated with root canal treatment.
Lastly, given important issues of cost and toxicity, future randomized-controlled trials identifying optimal dose and length of treatment would be very helpful in optimizing use of bevacizumab for glioblastoma patients.
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