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Results demonstrate that PSO was able to find good correction transformations, which can be used to better project future dose distributions and, consequently, improve decision making support.
These approaches let the emerging data determine the future dose increment subject to a cap rather than a fixed algorithm [ 9].
Nontraditional end points such as measurements of drug effect or functional imaging have not been routinely incorporated into phase I trial design and have rarely formed the basis for future dose selection or trial design (Parulekar and Eisenhauer, 2004).
The "future" data file contained the required timings of the future dosages, an initial guess at the likely future dose that would be required to achieve desired concentration targets (in this case 4 g), the required piperacillin target concentration, and the timing of the target.
With regard to a future dose escalation study, it has to be stated that a 2 mCi/kg (LBM) starting dose for the first cohort is at the lower end of the range of administered activity in our patients (Table 1 of Supplementary information) and provides room for a reasonable escalation of the subsequent cohorts and/or multiple doses of I-MIP-1095.
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If the drug wore off sooner, patients could be at risk of anticipating future doses and beginning a cycle of dependence.
He declined to say how much Bristol-Myers expected to earn from Vaniqa or whether it hopes to sell future doses of injectable eflornitine at cost or at a profit.
We evaluated the pharmacokinetics and dose-exposure relationships of high-dose Epo in this population to inform future dosing strategies.We performed a population pharmacokinetic analysis of 47 neonates with HIE treated with hypothermia who received up to six doses of Epo in two previous clinical trials.
It will also allow to consider in the future dose-response curves and domains for dose ranges different from that introduced according to (Tian et al. 2009) in Section 1.
Our findings may be generalised for similar future dose-intensive regimens used in breast cancer and those currently in use for other cancer sites (e.g., lymphomas).
The meta-analysis provides the best current evidence on the potential role of albumin dose selection in improving outcomes of treatment for type 1 HRS and furnishes guidance for the design of future dose-ranging studies.
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