It heralded the birth of jazz fusion, triggered solo careers for Zawinul, McLaughlin, Corea, drummer Jack DeJohnette, organist Larry Young and others - and nourished later chemistries of jazz and funk that have led to creative crossovers with hip-hop and other pop forms today.
Fusion triggered by propranolol was temporally regulated, similar to that observed in H-89 treated cells.
Fusion triggered by SR 59230A (50 µM), a selective β3-AR antagonist, also followed a similar pattern with fusion ceasing 34.6±4.1 min after initiation.
Imaging of Plin A-YFP labelled LDs in a single x y slice clearly showed continuation of the membrane during fusion triggered by SR 59230A (Fig. 3c).
Normal and cancer cells undergoing cell-cell fusion triggered by such fusogens, such as the endogenous retroviral protein ERVWE1 or the measles virus (MV), display characteristics of cellular senescence [ 1].
In addition, since MFN1 can efficiently tubulate mitochondria in the presence of OPA1 (38), they indicate that the overall amount of long and short OPA1 isoforms present in Afg3l2-depleted cells is sufficient to respond to fusion induction triggered by MFN1.
First, do all ALL-1 fusions, including self-fusions, trigger a single pathway leading to disease?
Association of the SNAREs underlies the priming reaction (Walter et al. 2010), and final C-terminal-SNARE-assembly coincides with fusion-triggering (Sørensen et al. 2006).
The results from the oligonucleotide array analysis demonstrate that the three tyrosine kinase fusions trigger both overlapping and distinct gene expression changes, and these results were confirmed by Q-PCR (Table 5).
Loss of telomere protection occurs during physiological cell senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telomere-binding factor TRF2. Subsequently formed telomere fusions trigger rampant genomic instability leading to cell death or tumorigenesis.
