Exact(8)
FUSION identified 5′-hydroxy-staurosporine, which competitively inhibits AMPK.
This novel MET fusion identified in a C.3 tumor may also increase the cell division rate.
Comparing the gene expression signature of Compound C (also known as Dorsomorphin), a drug known to inhibit AMPK14, with fractions isolated from the natural product library, FUSION identified several fractions whose biologic activity was similar to Compound C treatment7,28.
Previously, FUSION identified AMPKγ1 as a genetic functional analog of KSR1 based on unsupervised hierarchical clustering and quantification of similarity metrics (Euclidean distance and Pearson correlation) based on reporter gene expression following RNAi-mediated depletion of individual genes from a genome-scale human siRNA library.
In this instance, FUSION identified 5-OH-S as an inhibitor of AMPK, which can serve as a lead compound that can be used to understand AMPK activity and could be further developed using medicinal chemistry for use as a cancer therapeutic.
Signal fusion identified physiological events that included atrial fibrillation, elevated blood pressure, extreme distress and oxygen desaturation.
Similar(52)
FUSION identifies an AMPK inhibitor.
Contrasting populations of D. americana that differ in the frequency of the X-4 fusion identifies immediate effects associated with a localized reduction in the rate of meiotic recombination.
We use these data to investigate the evolutionary ancestry of the three-domain pterin biosynthesis gene fusion, identifying: a diversity of gene fusion architectures, gene fission events, and a number of gene losses.
Examples include monitoring the strength and progression of fracture healing and spine fusion; identifying risk for implant fatigue, migration and loosening; and monitoring of wear and damage in bearing surfaces.
PVT1 fusions identified in this study involve only PVT1 exon 1 and miR-1204.
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