Sentence examples for fusion hallmarks from inspiring English sources

Dicentric and end-to-end chromatid fusion, hallmarks of a defective NHEJ, were the most common abnormalities seen in the W438 hPolλ expressing cells.

It can also lead to translocations and telomere fusion, hallmarks of tumor cells [ 19].

Expression of plasmid-encoded paramyxovirus envelope glycoproteins in receptor-positive cells typically results in extensive cell-to-cell fusion, the hallmark cytopathic effect associated with most paramyxovirus infections in vitro [1].

t(9 22) generates the BCR-ABL fusion gene, the hallmark of chronic myeloid leukemia (CML) but also found in acute lymphoblastic leukemia (ALL).

EWS-FLI1 fusion protein, the hallmark of Ewing's sarcoma, downregulates insulin-like growth factor binding protein 3, IGFBP3, and upregulates IGF-1 expression resulting in enhanced IGF1R [25].

Finally, we demonstrated that PU.1 expression is critically suppressed by the PML-RARA fusion protein, the hallmark of AML-M3 patients (Mueller et al, 2006).

doi: 10.7554/eLife.02272 Image Proteins that ensure proper membrane fusion One of the hallmarks of eukaryotic cells is that they contain a number of distinct compartments called organelles.

In human chronic myelogenous leukemia (CML), an aberrant BCR-ABL fusion transcript is the hallmark of the disease [ 24].

Independent events of gene fusion are considered a hallmark of functional coupling that can be also present in those species in which a similar gene fusion is not observed [ 50].

In addition to ATM-dependent checkpoint signalling, end-to-end fusions are a hallmark of TRF2 inactivation (Palm & de Lange, 2008).

Whereas a wild-type yeast strain has one or a few vacuoles, deletion of PLC1, encoding a phospholipase C which generates diacylglycerol, causes striking vacuole fragmentation (Jun et al., 2004), a hallmark of defective fusion (Wada et al., 1992).